Construction of 3-Hydroxyindolin-2-ones via Ru(II)-Catalyzed Domino Alkylation/Cyclization/Oxidation of
Chuanhu Wang1, Jingwen Huang1, Bo Deng1
1Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, National Demonstration Center for Experimental Chemistry Education, College of Chemistry & Materials Science, Northwest University, 1 Xuefu Road, Xi'an, Shaanxi 710127, P. R. China.
Abstract:
A novel Ru(II)-catalyzed domino reaction, comprising alkylation, cyclization, and oxidation of 2-aminophenethanols with benzyl alcohols, has been developed for the synthesis of 3-hydroxyindolin-2-ones. This transformation exhibits excellent synthetic efficiency, enabling the selective formation of four or three σ bonds, one π bond, and one quaternary carbon center in one step under identical conditions. Furthermore, it provides a versatile approach to 3-hydroxyindolin-2-one frameworks with distinct substituents at the 1- and 3-positions.
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