Risk of CIN2+ in women aged >60 years with abnormal cervical cancer screening: a multicenter retrospective cohort study from the Thai Gynecologic Cancer Society research group
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Cervical cancer screening in women over 60 should be individualized. Lack of prior screening and high-grade cytology are key predictors for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).
Area Of Science
- Gynecology
- Oncology
- Public Health
Background
- Cervical cancer screening guidelines often focus on younger populations.
- Older women (>60 years) with abnormal screening results require further investigation.
- Understanding risk factors for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in this demographic is crucial.
Purpose Of The Study
- To analyze patterns of abnormal cervical cancer screening in women over 60.
- To determine the risk and identify predictors of CIN2+ in this age group.
Main Methods
- Retrospective cohort study of 1,596 women aged >60 with abnormal cervical cancer screening.
- Data collected included patient characteristics, screening history, and histopathology.
- Exclusion of women who underwent hysterectomy.
Main Results
- The risk of CIN2+ was 17.9% in women with abnormal screening.
- Independent predictors for CIN2+ included lack of previous screening (aOR 4.05) and high-grade cytology (aOR 7.00).
- Other significant univariable predictors included age >70, recent sexual activity, prior abnormal screening or CIN2+, and symptoms.
Conclusions
- Cervical cancer screening continuation in women >60 should be risk-stratified.
- Individualized screening approaches are recommended, especially for women with no prior screening history.
- Focusing on risk factors can optimize screening strategies for older women.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...