Biofouling-resistant nanomaterials for non-enzymatic glucose sensors: A critical review

Biofouling is a significant concern in sensors and diagnostic applications as it results in reduced sensitivity, selectivity, and response time, false signals or noise, and ultimately causes a reduction in the sensor lifespan. This is particularly a concern while developing non-enzymatic glucose sensors (NEGS) that can be used to fabricate implantable sensors for continuous glucose monitoring. Thus, developing advanced materials solutions in the form of nanomaterials that display inherent antifouling activity is imperative. Due to their small nanosized dimensions and tunable microstructures, nanomaterials display unique physio-chemical properties that display antifouling efficiency and thus can be applied towards developing highly stable, sensitive, and selective NEGS. Through this review, we aim to explore the recent advances in the field of antifouling nanomaterials that offer promising potential to be applied towards developing NEGS. We discuss the details of various biofouling-resistant nanomaterials, including graphene and graphene oxide, carbon nanotubes, gold nanoparticles, silver nanoparticles, metal oxide nanoparticles, and polymeric nanocomposites. Further, we highlighted the possible mechanism of action involving nanomaterials in providing antifouling features in NEGS, followed by a brief discussion of the advantages and disadvantages of using nanomaterials for antifouling in developing NEGS. Finally, we concluded the article by proposing the future prospects of this promising technology.