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MTD: A cloud-based omics database and interactive platform for Myceliophthora thermophila.

Jiacheng Dong1,2,3,4, Zhitao Mao5,4, Haoran Li5,4

  • 1State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Synthetic and Systems Biotechnology
|April 25, 2025
PubMed
Summary

A new database, MTD, was created for the thermophilic fungus Myceliophthora thermophila. This resource aids industrial enzyme production research by providing integrated omics data and analysis tools.

Keywords:
DatabaseMyceliophthora thermophilaOmics dataServerless architecture

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Area of Science:

  • Mycology
  • Bioinformatics
  • Systems Biology

Background:

  • Biological databases are crucial for modern research.
  • Myceliophthora thermophila is a key fungus for industrial applications, but lacks a dedicated database.
  • Limited data accessibility hinders M. thermophila research and reanalysis.

Purpose of the Study:

  • To develop a comprehensive, cloud-based omics database and interactive platform for M. thermophila.
  • To streamline M. thermophila research by integrating diverse data types and analysis tools.
  • To facilitate data reproduction, querying, and mining for M. thermophila.

Main Methods:

  • Developed MTD, a cloud-based platform integrating genome annotations, predictions, transcriptome data, and experimental details.
  • Implemented a 'top-down' search strategy for efficient data retrieval.
  • Integrated bioinformatics analysis tools for in-depth data mining.

Main Results:

  • MTD provides a one-stop solution for M. thermophila research.
  • Analysis using MTD revealed metabolic shifts in a glucoamylase hyperproduction strain.
  • Identified changes in fatty acid and amino acid biosynthesis pathways.

Conclusions:

  • MTD is a pioneering resource advancing M. thermophila research.
  • The database facilitates novel insights into fungal physiology and strain improvement.
  • MTD serves as a model for developing similar databases for other species.