Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Migration00:53

Migration

7.8K
Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
7.8K
Symbiosis00:58

Symbiosis

27.0K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.0K
Theorems of Pappus and Guldinus: Problem Solving01:12

Theorems of Pappus and Guldinus: Problem Solving

664
Pappus and Guldinus's theorems are powerful mathematical principles that are used for finding the surface area and volume of composite shapes. For example, consider a cylindrical storage tank with a conical top. Finding the surface area or volume can be challenging for such complex shapes. These theorems are particularly useful in calculating the volume and surface area of such systems. Here, the cylindrical storage tank with a conical top can be broken down into two simple shapes: a...
664
Spanning Openings in Brick Walls01:20

Spanning Openings in Brick Walls

148
In brick wall construction, supporting structures are crucial for openings like windows and doors to maintain the integrity and support the weight of the wall above. These supports include lintels, corbels, and arches, each serving specific structural purposes.
Lintels are primary supports used to span openings and can be crafted from materials such as reinforced concrete, steel-reinforced brick masonry, or simple steel angles. These are straightforward to install and are typically concealed...
148
Schemas01:42

Schemas

11.5K
A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
11.5K
Design of Columns under an Eccentric Load01:21

Design of Columns under an Eccentric Load

372
Designing columns to withstand eccentric loads is a critical aspect of structural engineering, ensuring structures can support off-center loads without failure. This design process must account for the additional normal stresses introduced by eccentric loading, which can significantly influence a column's stress distribution and overall stability. An eccentric load applied to a column induces normal stresses that can be conceptualized as a combination of stresses due to an equivalent...
372

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ploidy shapes gemcitabine response through altered potency and delayed cell death.

bioRxiv : the preprint server for biology·2026
Same author

Pharmacokinetic Acceleration via CYP3A4 Hyperactivation as a Clinically Actionable Mechanism of Targeted Therapy Resistance in NSCLC.

bioRxiv : the preprint server for biology·2026
Same author

A provocative view of evolution turns 50<b>The Selfish Gene: 50th Anniversary Edition</b> <i>Richard Dawkins</i> Oxford University Press, 2026. 544 pp.

Science (New York, N.Y.)·2026
Same author

When effective anticancer therapies are, in fact, destabilizing the tumor's Group Phenotypic Composition.

NPJ precision oncology·2026
Same author

Age identifies cancer drivers hidden within the genome.

Nature genetics·2026
Same author

Multifactorial sheltering in peristromal niches shapes in vivo responses of lung cancers to targeted therapies.

Nature communications·2026
Same journal

Built environment is a key driver of cardiometabolic health in two Indigenous groups undergoing rapid lifestyle change.

Evolution, medicine, and public health·2026
Same journal

Adaptive therapy and its challenges.

Evolution, medicine, and public health·2026
Same journal

Competitive suppression and release in artemisinin-resistant <i>Plasmodium falciparum</i> field isolates.

Evolution, medicine, and public health·2026
Same journal

An evolutionary medicine perspective on the design of non-hormonal contraceptives for women.

Evolution, medicine, and public health·2026
Same journal

Daughters-in-law and mothers-in-law in lowland rural Nepal: The balance of power and health outcomes.

Evolution, medicine, and public health·2026
Same journal

Cancer, collapse, and the politics of somatic evolution.

Evolution, medicine, and public health·2026
See all related articles

Related Experiment Video

Updated: May 10, 2025

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton
08:02

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton

Published on: May 7, 2016

9.7K

The Elephant and the Spandrel.

Zachary T Compton1,2, J Arvid Ågren3,4, Andriy Marusyk5

  • 1University of Arizona Cancer Center, Tucson, AZ, USA.

Evolution, Medicine, and Public Health
|April 25, 2025
PubMed
Summary
This summary is machine-generated.

Cancer evolution studies may overstate cancer suppression. Focusing on somatic maintenance offers a better evolutionary perspective on cancer variation across species.

More Related Videos

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

5.7K
Microinjection for Transgenesis and Genome Editing in Threespine Sticklebacks
08:51

Microinjection for Transgenesis and Genome Editing in Threespine Sticklebacks

Published on: May 13, 2016

13.9K

Related Experiment Videos

Last Updated: May 10, 2025

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton
08:02

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton

Published on: May 7, 2016

9.7K
The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

5.7K
Microinjection for Transgenesis and Genome Editing in Threespine Sticklebacks
08:51

Microinjection for Transgenesis and Genome Editing in Threespine Sticklebacks

Published on: May 13, 2016

13.9K

Area of Science:

  • Evolutionary biology
  • Comparative oncology

Background:

  • Comparative oncology identifies cancer prevalence patterns across species.
  • Studies often focus on cancer suppression mechanisms, particularly in large animals like elephants.
  • Existing conclusions may be exaggerated, as cancer suppression might be an evolutionary byproduct.

Purpose of the Study:

  • To propose a novel evolutionary perspective on cancer variation.
  • To highlight the importance of somatic maintenance as a driver of natural selection.
  • To reframe research from cancer suppression to somatic maintenance for deeper insights.

Main Methods:

  • Reviewing evolutionary origins of multicellularity.
  • Analyzing comparative oncology findings.
  • Proposing a shift in research focus.

Main Results:

  • Cancer suppression mechanisms may not have evolved primarily for cancer prevention.
  • Somatic maintenance is proposed as the core evolutionary pressure.
  • A new framework for understanding cancer variation is suggested.

Conclusions:

  • Shifting focus to somatic maintenance provides a more accurate evolutionary understanding of cancer prevalence.
  • This approach can illuminate the evolutionary pressures shaping species-specific cancer resistance.