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Published on: December 15, 2023
Enhanced precision in prostate surgery: determining key factors for rectal positive surgical margins through
Yufan Wu1,2, Fei Liu3, Shiyu Ma4
1Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Objective:
This study investigates the risk factors associated with rectal positive surgical margins (RPSM) following radical prostatectomy and aims to develop a predictive model.
Methods:
Clinical data from 198 patients undergoing radical prostatectomy at the Department of Urology, Kunshan Hospital of Traditional Chinese Medicine from June 2022 to June 2024 were analyzed. Patients were categorized into groups with and without RPSM. Univariate and multivariate logistic regression analyses identified independent predictors of RPSM. Utilizing R software, we generated a column chart illustrating prostate cancer's RPSM incidence and constructed ROC curves with the area under the curve (AUC) to assess the discriminative performance and calibration of our model.
Results:
Multivariate logistic regression identified clinical stage, PSA level, Gleason score, bilateral prostate infiltration, and PI-RADS as significant predictors of RPSM (all P < 0.05). Using these predictors, we developed a nomogram that achieved a C-index of 0.833(95% CI: 0.785-0.887) and an AUC of 0.755 (95% CI: 0.645-0.866).
Conclusion:
The predictive model effectively forecasts the likelihood of RPSM following radical prostatectomy, offering valuable insights for personalized patient management.
