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Updated: May 10, 2025

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Left Atrial Appendage Thrombus in Low CHA2DS2VASc Score in Persistent Atrial Fibrillation
Ezelea Elwina Walter Sandosam1, Mohd Khairi Othman1, Krishinan Saravanan2
1Internal Medicine, Universiti Sains Malaysia School of Medical Sciences, Kota Bharu, MYS.
Cureus
|April 25, 2025
Summary
Patients with atrial fibrillation and low stroke risk scores can still develop dangerous left atrial appendage thrombus. This case highlights the need for better stroke risk assessment beyond current scoring systems to prevent cardioembolic events.
Area of Science:
- Cardiology
- Neurology
Background:
- Atrial fibrillation (AF) is a common arrhythmia, increasing stroke risk.
- The left atrial appendage (LAA) is the primary source of cardioembolic stroke in AF patients.
- Current stroke risk stratification, like the CHA₂DS₂VASc score, doesn't fully account for LAA thrombus.
Keywords:
anticoagulantleft atrial appendage thrombuspersistent atrial fibrillationpulmonary vein isolationstroke
