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Knee Joint

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

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Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

A Systematic Review of all Published Systematic Reviews (SRs) on Multiligament Knee Injuries (MLKIs).

Nagashree Vasudeva¹, Ajay Gowtham Amutham Elangovan², Rajagopalakrishnan Ramakanth³

¹Mahaveer Medical Centre, Mangalore, India.

Indian Journal of Orthopaedics

|April 25, 2025

Summary

This review found a scarcity of high-quality systematic reviews on multiligament knee injuries (MLKIs). Most existing research on MLKIs is of low quality, necessitating improved reporting and further studies.

Keywords:

ACL tear LCL/PLC tear MCL/PMC tear Multiligament knee injuries (MLKIs)PCL tear

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Area of Science:

Orthopedics
Sports Medicine
Knee Surgery

Background:

Multiligament knee injuries (MLKIs) are complex and heterogeneous.
Standardized reporting and optimal management strategies for MLKIs remain debated.
A comprehensive understanding of current evidence is crucial for evidence-based decision-making.

Purpose of the Study:

To systematically review and synthesize existing systematic reviews and meta-analyses on MLKIs.
To identify strengths and weaknesses in the current evidence base for MLKIs.
To pinpoint areas requiring further research to enhance patient care.

Main Methods:

Systematic review adhering to PRISMA guidelines.
Searches conducted in PubMed, Embase, and Cochrane Library.
Methodological quality assessed using AMSTAR 2 criteria; inter-rater reliability measured with Cohen's kappa.

Main Results:

A total of 36 systematic reviews were identified and assessed.
The majority of systematic reviews (n=26) demonstrated critically low methodological quality.
A significant portion of reviews were rated as low (n=8) or moderate (n=3) quality, with only one high-quality review.

Conclusions:

There is a notable scarcity of high-quality systematic reviews concerning MLKIs.
The heterogeneity in injury patterns, management, and reporting standards contributes to the limited high-quality evidence.
Further research with improved reporting standards is essential to advance the understanding and treatment of MLKIs.