Related Experiment Video

Updated: May 10, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

711

Rare Case Report of Ticagrelor-Induced Hepatotoxicity

Dong Wook Kim1, Song-Hee Han2, Yeo Wool Kang1

  • 1Department of Internal Medicine, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|April 25, 2025
PubMed

Insights

Ticagrelor, a P2Y12 inhibitor, can cause liver injury. This case report details drug-induced liver injury from ticagrelor, emphasizing monitoring liver function in patients on this medication.

Area of Science:

  • Hepatology
  • Pharmacology
  • Cardiology

Background:

  • Ticagrelor is a potent P2Y12 receptor inhibitor widely used for acute coronary syndrome.
  • It demonstrates superior efficacy over clopidogrel in reducing cardiovascular events.
  • Ticagrelor generally has a favorable safety profile.

Observation:

  • A 66-year-old male with pituitary macroadenoma presented with asymptomatic elevated liver enzymes.
  • Liver biopsy revealed lymphocytic infiltrate with eosinophils and plasma cells in zone 3 hepatic parenchyma.
  • Initial discontinuation of antiplatelet drugs led to improvement, followed by worsening after biopsy.

Findings:

  • Ticagrelor was suspected as the causative agent for drug-induced liver injury (DILI).
  • Discontinuation of ticagrelor resulted in the gradual normalization of liver enzyme levels.
  • Histopathological findings were consistent with drug-induced liver injury.

Implications:

  • This case highlights a rare instance of ticagrelor-induced hepatotoxicity.
  • It underscores the importance of vigilant liver function monitoring in patients prescribed ticagrelor.
  • Clinicians should consider DILI in patients on ticagrelor presenting with unexplained liver enzyme elevation.

Keywords:
Acute coronary syndromeBiopsy, liverDrug-induced liver injuryLiver diseases, drug-InducedTicagrelor

More Related Videos

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.2K
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.2K

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
388
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
744
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
123
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
997
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
4.0K