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Updated: May 10, 2025

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
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Integrating Optical Genome Mapping With TP53 FISH: A Synergistic Approach for Cytogenomic Analysis in Chronic

Joanna Kamaso1,2,3, Rocío García-Serra4,5,6, Marina Munné1,2

  • 1Molecular Cytogenetics Laboratory, Pathology Department, Hospital del Mar, Barcelona, Spain.

American Journal of Hematology
|April 25, 2025
PubMed
Summary

No abstract available in PubMed .

Keywords:
chromoanagenesischromosome banding analysischronic lymphocytic leukemiacomplex karyotypefluorescence in situ hybridizationoptical genome mapping

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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