Corneal neurotization for the treatment of neurotrophic keratopathy

Corneal neurotization, a surgical technique that restores corneal sensation by transferring a healthy sensory nerve to the neurotrophic cornea, has emerged as a treatment of moderate to severe neurotrophic keratopathy. This review provides an overview of the indications, surgical techniques, and outcomes of corneal neurotization.

Corneal neurotization can be performed via direct nerve transfer or indirect nerve grafting, with comparable long-term outcomes. Advances such as minimally invasive and endoscopic techniques, nerve allografts, and alternative donor nerves have expanded its accessibility. Studies show significant improvements in corneal sensation, epithelial integrity, and ocular surface health, with younger patients achieving faster and more complete recovery. The procedure has demonstrated efficacy across diverse neurotrophic keratopathy etiologies and is increasingly considered earlier in disease progression.

Corneal neurotization offers a promising, long-term solution for neurotrophic keratopathy by addressing the root cause of corneal anesthesia.