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dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction
Pak-Hin Hinson Cheung1, Hua Yang1, Li Wu1
1Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Abstract:
SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.
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