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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Related Experiment Video

Updated: May 10, 2025

Experimental Model of Ligature-Induced Peri-Implantitis in Mice
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Exploring Peri-Implantitis Risk-Factors: A Cross-Sectional Study.

Simina Angela Lăcrimioara Iușan1, Ondine Patricia Lucaciu1, Nausica Bianca Petrescu1

  • 1Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

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|April 25, 2025
PubMed
Summary

Peri-implantitis involves complex polymicrobial infections, with both pathogenic and opportunistic bacteria playing key roles. Understanding these microbial factors is crucial for effective dental implant treatment and prevention strategies.

Keywords:
bacteriadental implantsgendermicrobiologyperi-implantitissmoking

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Area of Science:

  • Dentistry
  • Microbiology
  • Periodontology

Background:

  • Dental implants are increasingly used in edentulous patients.
  • Peri-implantitis, an inflammatory condition, affects a significant number of implants.
  • Understanding the microbial etiology and risk factors for peri-implantitis is critical.

Purpose of the Study:

  • To identify predominant bacterial species in Romanian patients with peri-implantitis.
  • To compare microbial profiles between healthy and peri-implantitis affected implant sites.
  • To examine the influence of smoking, gender, age, and prosthetic type on peri-implantitis prevalence.

Main Methods:

  • Cross-sectional study conducted from January 2023 to December 2024.
  • Inclusion of 22 patients and 50 implants from two private dental clinics in Cluj-Napoca, Romania.
  • Microbiological analysis using the Vitek 2 Compact System for bacterial identification.

Main Results:

  • Peri-implantitis incidence was independent of gender and smoking status.
  • The condition was more prevalent in the mandible.
  • Peri-implantitis is characterized by a polymicrobial infection involving pathogenic and opportunistic bacteria.

Conclusions:

  • Peri-implantitis is a complex polymicrobial infection resulting from interactions between pathogenic and opportunistic bacteria.
  • Local, systemic, and microbial factors contribute to peri-implantitis development.
  • Further research on opportunistic bacteria is essential for effective peri-implantitis treatment and management.