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Updated: May 10, 2025

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
Published on: December 13, 2017
Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers
Lakshmi V Nair1, Jarred Wheeler1, Yaelyn Ha1
1Department of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Abstract:
Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be effectively utilized for the same purpose. The early detection of heart diseases can be evaluated by monitoring the troponin level. A copper nanoparticle-mediated troponin biosensor was developed through antibody conjugation for troponin I and troponin T. The copper nanosensor shows a concentration-dependent SPR change towards troponin T and troponin I.
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