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Related Experiment Video

Updated: May 4, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Single-Cell Endoscopy for Multifunctional Live-Cell Molecular Analysis.

Haoze Xue¹, Li Wang¹, Han Yao¹

¹School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.

|April 25, 2025

Summary

This summary is machine-generated.

Single-cell endoscopy offers advanced live-cell analysis for understanding diseases and drug discovery. This technique enables precise intracellular manipulation and sensing, advancing molecular diagnostics.

Keywords:

high resolution live-cell technique molecular analyses single-cell analysis single-molecule sensitivity

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Published on: December 23, 2022

Area of Science:

Biotechnology
Cellular Biology
Medical Technology

Background:

High-resolution molecular analysis of single cells is crucial for understanding disease mechanisms and accelerating drug discovery.
Cellular heterogeneity necessitates advanced techniques for in-depth cellular investigation.

Purpose of the Study:

To review recent advancements in single-cell endoscopy techniques over the past decade.
To highlight the fundamental considerations, fabrication, and characterization of live-cell endoscopes.
To explore applications in intracellular molecular sensing and delivery.

Main Methods:

Summarizing predominant live-cell endoscope designs and their fabrication processes.
Reviewing applications of single-cell endoscopy for sensing nucleic acids, proteins, and ions.
Analyzing the merits and capabilities of single-cell endoscopy in molecular analysis.

Main Results:

Single-cell endoscopy provides minimally invasive probing of individual cell interiors.
The technique demonstrates promise in flexible single-cell manipulation, ultrasensitive sensing, and precise intracellular delivery.
Recent progress has expanded its utility in various intracellular molecular sensing events.

Conclusions:

Single-cell endoscopy is a powerful tool for detailed cellular analysis, offering significant advantages over other single-cell techniques.
Future development holds potential for further enhancing its capabilities in disease research and therapeutic applications.
The review outlines current challenges and future directions for this evolving technology.