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Innovative Methodologies for the Early Detection of Breast Cancer: A Review Categorized by Target Biological Samples.
Antonella Grasso1, Vittorio Altomare1, Giulia Fiorini2
1Breast Unit, Policlinico Campus Bio-Medico di Roma, 00128 Rome, Italy.
Biosensors
|April 25, 2025
Summary
Innovative biosensors offer a promising, non-invasive approach to early cancer detection, complementing traditional methods. Further research and standardization are key for wider adoption and improved patient outcomes.
Area of Science:
- Biomedical Engineering
- Oncology
- Diagnostic Technologies
Background:
- Conventional cancer screening methods (e.g., mammography, MRI) are effective but invasive, costly, and require specialized infrastructure.
- Limitations of current screening include invasiveness, high costs, and patient discomfort, hindering early detection and frequent monitoring.
- There is a growing need for accessible, non-invasive, and cost-effective cancer detection technologies.
Purpose of the Study:
- To explore the potential of innovative biosensor technologies for revolutionizing cancer detection.
- To evaluate the use of non-invasive samples (breath, saliva, urine, sweat) and advanced analytical techniques, including AI, for early cancer diagnosis.
- To compare the advantages of biosensor-based approaches with conventional screening methods.
Main Methods:
- Analysis of non-invasive biological samples (breath, saliva, urine, sweat) using advanced biosensor technologies.
- Integration of artificial intelligence (AI) for enhanced data analysis, pattern recognition, and personalized diagnostics.
- Review and comparison of biosensor performance against established diagnostic benchmarks and conventional screening modalities.
Main Results:
- Biosensor technologies demonstrate potential for non-invasive, sensitive, and rapid cancer detection, addressing limitations of conventional screening.
- Non-invasive samples analyzed with AI show promise for early detection and monitoring, though require further validation.
- Biosensor methods offer reduced infrastructure needs and lower costs compared to traditional diagnostics.
Conclusions:
- Integrating biosensor technologies with conventional methods offers a comprehensive approach, balancing reliability with accessibility.
- Future research should focus on biosensor development, standardization, validation, and cost-effectiveness for broader clinical application.
- The future of cancer detection lies in a multi-modal approach, combining sensitive, specific, and patient-friendly screening strategies to improve early diagnosis and patient outcomes.

