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MMP3 as a Molecular Link: Unraveling the Connection Between Ankylosing Spondylitis and Acute Coronary Syndrome

Iliannis Y Roa-Bruzón1,2, Luis F Duany-Almira1,2, Yeminia M Valle-Delgadillo1

  • 1Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Ciencias Biomédicas (IICB), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.

Cells
|April 25, 2025
PubMed

Insights

Ankylosing spondylitis patients face higher cardiovascular risks due to chronic inflammation. Matrix metalloproteinase 3 (MMP-3) plays a key role in this process, highlighting potential therapeutic targets.

Area of Science:

  • Rheumatology
  • Cardiology
  • Molecular Biology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory condition impacting joint health and patient quality of life.
  • AS patients exhibit an elevated risk for severe cardiovascular complications, including acute coronary syndrome (ACS).

Purpose of the Study:

  • To evaluate the role of matrix metalloproteinase 3 (MMP-3) in cardiovascular risk among patients with ankylosing spondylitis.
  • To explore the molecular mechanisms linking AS inflammation to cardiovascular disease progression.

Main Methods:

  • Comprehensive literature review (2014-2024) focusing on AS, cardiovascular risk, and MMP-3.
  • Analysis of molecular pathways involving MMP-3, tumor necrosis factor-alpha (TNF-α), and NF-κB in AS pathogenesis.

Main Results:

  • Chronic inflammation in AS contributes significantly to cardiovascular disease progression.
  • MMP-3 degrades extracellular matrix, destabilizing atherosclerotic plaques and increasing ACS risk.
  • MMP-3 activation is linked to inflammatory pathways (TNF-α, NF-κB), exacerbating joint and vascular damage.

Conclusions:

  • MMP-3 is a critical factor in the heightened cardiovascular risk observed in AS patients.
  • Targeting MMP-3 presents a potential therapeutic strategy to reduce cardiovascular complications in AS.
  • Understanding the molecular interplay between AS and cardiovascular disease opens new treatment avenues.

Keywords:
acute coronary syndromeankylosing spondylitiscardiovascular riskchronic inflammationextracellular matrix degradationmatrix metalloproteinase 3 (MMP-3)

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