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Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Related Experiment Video

Updated: Apr 15, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
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Intraoperative Hemoadsorption in Heart Transplant Surgery: A 5-Year Experience.

Nikola Sliskovic1, Gloria Sestan1, Savica Gjorgjievska1

  • 1Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10000 Zagreb, Croatia.

Journal of Cardiovascular Development and Disease
|April 25, 2025
PubMed
Summary

Intraoperative hemoadsorption (HA) in heart transplantation reduced blood product use and mechanical ventilation time. This cytokine removal therapy may improve immediate outcomes but requires further study in larger trials.

Keywords:
CytoSorbcardiac surgerycytokinesheart transplantationhemoadsorption

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Area of Science:

  • Cardiology
  • Transplantation Surgery
  • Critical Care Medicine

Background:

  • Orthotopic heart transplantation (HTx) can trigger hyperimmune responses and cytokine release post-reperfusion.
  • Intraoperative hemoadsorption (HA) is a potential strategy to mitigate these effects by removing elevated cytokines.

Purpose of the Study:

  • To evaluate the impact of intraoperative hemoadsorption (HA) on patient outcomes following orthotopic heart transplantation (HTx).

Main Methods:

  • A comparative study of 40 HTx patients undergoing intraoperative HA versus 41 historical controls between 2018-2022.
  • Outcomes assessed included hemodynamic stability, blood product needs, acute kidney injury requiring dialysis (AKI-d), and 30-day mortality.

Main Results:

  • The hemoadsorption group showed significantly reduced red blood cell (765 vs. 1330 mL) and fresh frozen plasma (945 vs. 1200 mL) transfusions.
  • Mechanical ventilation duration was shorter (22 vs. 28 hours) in the HA group.
  • While AKI-d rates were similar, 30-day mortality was non-significantly lower in the HA group (5% vs. 14.6%).

Conclusions:

  • Intraoperative hemoadsorption may enhance immediate postoperative recovery in heart transplant recipients.
  • Further investigation through larger randomized controlled trials is necessary to confirm these preliminary findings.