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Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs
Xiaofei Zhai1,2, Xinrong Geng1,2, Wenjun Li1,2
1Research Institute of Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.
Marine Drugs
|April 25, 2025
Summary
Marine collagen offers a safe and abundant biomaterial for bone repair. Cross-linking enhances its properties, improving its potential for bone tissue engineering applications and overcoming limitations of other materials.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Orthopedic Research
Background:
- Bone tissue injuries present significant challenges in repair.
- Current bone graft materials face limitations such as sourcing difficulties and immune rejection.
- Marine-derived collagen emerges as a promising alternative due to its abundance and safety profile.
Purpose of the Study:
- To review marine collagen modification methods for bone repair.
- To analyze the impact of cross-linking on marine collagen's properties.
- To establish the potential of modified marine collagen in bone tissue engineering.
Main Methods:
- Literature review of marine collagen modification techniques.
- Analysis of cross-linking strategies and their effects on collagen properties.
- Evaluation of marine collagen's suitability for bone regeneration.
Main Results:
- Marine collagen is abundant, safe, and avoids religious/disease concerns.
- Cross-linking improves mechanical strength and controls degradation rate.
- Modified marine collagen shows significant potential for bone defect repair.
Conclusions:
- Marine-derived collagen, particularly when cross-linked, is a viable biomaterial for bone tissue engineering.
- Further research into cross-linking methods can optimize its application in bone repair.
- This review provides a foundation for utilizing marine collagen in regenerative medicine.
