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Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

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Related Experiment Video

Updated: May 10, 2025

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

PD-L1/PD-1 Expression in the Treatment of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: An

Huda Moutaz Asmael Al-Azzawi¹, Syed Ameer Hamza¹, Rita Paolini¹

¹Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.

Journal of Personalized Medicine

|April 25, 2025

Summary

The PD-L1/PD-1 axis shows limited prognostic value for overall survival in oral cancer. However, PD-L1 expression correlates with specific clinicopathological features like sex, lymph node metastasis, and HPV status.

Keywords:

biomarker oral cancer oral potentially malignant disorders (OPMDs)oral squamous cell carcinomas programmed death ligand 1 programmed death receptor 1

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Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

Area of Science:

Oncology
Immunology
Oral Medicine

Background:

The PD-L1/PD-1 axis is a key regulator of immune responses and a target for cancer immunotherapy.
Understanding its role in oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) is crucial for personalized treatment.

Purpose of the Study:

To systematically review and synthesize evidence on the prognostic value of the PD-L1/PD-1 axis in OSCC and OPMDs.
To explore the potential of targeting this axis for personalized treatment strategies.

Main Methods:

Systematic search of six databases for systematic reviews and meta-analyses (SRMAs).
Inclusion of studies investigating PD-L1/PD-1 expression in OSCC/OPMD patients with survival or clinicopathological outcomes.
Risk of bias assessment using the AMSTAR 2 tool.

Main Results:

Five SRMA studies met the inclusion criteria.
Limited evidence supports the prognostic value of PD-L1 for overall survival in oral cancer.
PD-L1 expression correlated with sex, lymph node metastasis, and HPV status.

Conclusions:

The prognostic significance of PD-L1 for overall survival in oral cancer remains uncertain.
PD-L1 expression is associated with specific clinicopathological features in oral cancer patients.
Further research is needed to clarify the role of the PD-L1/PD-1 axis in OSCC/OPMDs and its therapeutic potential.