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Related Experiment Video

Updated: May 10, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical

Mykhailo Buchynskyi¹, Iryna Kamyshna², Iryna Halabitska³

¹Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.

Journal of Personalized Medicine

|April 25, 2025

Summary

This summary is machine-generated.

Genetic variations in interferon pathway and viral entry genes influence COVID-19 patient response to Paxlovid treatment. These genetic factors may affect immune response, coagulation, and clinical outcomes, suggesting personalized treatment strategies.

Keywords:

ACE2 COVID-19 IFNAR2 OAS1 OAS3 Paxlovid nirmatrelvir

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Published on: December 23, 2020

Area of Science:

Pharmacogenomics
Immunology
Virology

Background:

COVID-19 treatment response varies significantly among patients.
Paxlovid is a key antiviral therapy for COVID-19.
Genetic factors may underlie differential treatment efficacy.

Purpose of the Study:

To investigate the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 genes.
To determine if these polymorphisms predict Paxlovid treatment response in COVID-19 patients.
To examine the influence of genetic variations on clinical course and laboratory parameters.

Main Methods:

Analysis of specific gene polymorphisms: IFNAR2 rs2236757, OAS1 rs10774671, OAS3 rs10735079, and ACE2 rs2074192.
Study population included COVID-19 patients treated with Paxlovid.
Evaluation of clinical parameters (oxygen saturation, leukocyte count, liver function) and laboratory markers.

Main Results:

Genetic variations in IFNAR2, OAS1, and OAS3 were associated with altered inflammatory and coagulation markers.
Specific genotypes correlated with changes in clinical parameters in Paxlovid-treated patients.
Findings suggest genetic modulation of immune and coagulation pathways during Paxlovid therapy.

Conclusions:

Genetic polymorphisms in key immune and viral entry genes may influence Paxlovid efficacy.
Individual genetic makeup could predict treatment response and clinical outcomes.
Results support the development of personalized medicine approaches for COVID-19 treatment.