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Published on: July 3, 2018
The Relationship Between Clinical Features of Ischemic Stroke and miRNA Expression in Stroke Patients: A Systematic
Katarzyna Prus1, Konrad Rejdak1,2, Federico Bilotta3
1Department of Neurology, Stroke, and Early Post-Stroke Rehabilitation, University Clinical Hospital No. 4, 20-954 Lublin, Poland.
Abstract:
Background/Objectives: Ischemic stroke remains a leading cause of death and disability worldwide. Despite significant progress in reperfusion therapy, the optimal ischemic stroke management strategy has not been developed. Recent studies demonstrate that microRNA may play an essential role in the pathophysiology of ischemic stroke and its possible potential to be a treatment target point. The proposed systematic review aimed to report the relationship between IS's clinical severity and miRNA expression. Secondary outcomes included infarct volume, systemic inflammatory markers, and prognosis, as well as additional features such as stroke subtype, comorbidity, and risk of subsequent stroke in correlation to miRNA expression. Methods: We have performed a systematic search of database resources according to PRISMA statement guidelines. Twenty-seven studies on a total number of 3906 patients were assessed as suitable for the present SR. Included studies analyzed the expression of 30 different miRNA fragments. Results: After investigating available data, we have identified a set of possible miRNA fragment candidates that may be used in stroke diagnostics and have the potential to be a base for the development of future treatment protocols. Conclusions: Studies included in the presented SR indicate that miRNA expression may be significantly associated with clinical severity, infarct volume, and inflammation in ischemic stroke. More prospective, properly designed protocols with consistent methods of miRNA testing and optimized clinical assessment are needed to confirm the role of miRNA expression in the course of a stroke.
Insights
MicroRNA (miRNA) expression is linked to the severity and inflammation of ischemic stroke (IS). This systematic review identifies potential miRNA biomarkers for stroke diagnostics and future therapeutic targets.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Ischemic stroke (IS) is a major global health challenge causing death and disability.
- Current reperfusion therapies are insufficient for optimal ischemic stroke management.
- MicroRNAs (miRNAs) are emerging as key players in IS pathophysiology and potential therapeutic targets.
Purpose of the Study:
- To systematically review the relationship between clinical severity of IS and miRNA expression.
- To explore correlations between miRNA expression and infarct volume, inflammatory markers, and prognosis.
- To investigate associations with stroke subtype, comorbidities, and subsequent stroke risk.
Main Methods:
- A systematic literature search was conducted following PRISMA guidelines.
- Twenty-seven studies involving 3906 patients were included in the review.
- Analysis focused on the expression of 30 distinct miRNA fragments.
Main Results:
- A set of candidate miRNA fragments were identified for potential use in stroke diagnostics.
- These miRNAs show potential as a foundation for developing future treatment protocols.
- miRNA expression was found to be significantly associated with clinical severity, infarct volume, and inflammation in IS.
Conclusions:
- miRNA expression correlates significantly with clinical severity, infarct volume, and inflammation in ischemic stroke.
- Further prospective studies with standardized methods are required to confirm the role of miRNA expression in stroke.
- miRNAs represent a promising area for developing novel diagnostic and therapeutic strategies for IS.
