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Exploring the Association Between Sleep Patterns, Pubertal Health, and Phthalate Exposure-Preliminary Results from

Martina Jahnátková1, Henrieta Hlisníková2, Ida Petrovičová1

  • 1Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia.

Toxics
|April 25, 2025
PubMed

Insights

Childhood phthalate exposure may be linked to sleep disturbances, with nonlinear effects observed for certain metabolites. Further research in larger cohorts is needed to confirm these findings and their health implications.

Area of Science:

  • Environmental Health
  • Pediatric Sleep Medicine
  • Toxicology

Background:

  • Childhood exposure to phthalates is a growing public health concern.
  • Understanding the impact of environmental chemicals on child development is crucial.
  • Sleep disturbances in children can have long-term health consequences.

Purpose of the Study:

  • To investigate the association between phthalate exposure and sleep patterns in children.
  • To assess potential health implications of phthalate exposure on pediatric sleep quality.

Main Methods:

  • 60 children completed the Pittsburgh Sleep Quality Index (PSQI).
  • Urine samples analyzed for phthalate metabolites using high-performance liquid chromatography-tandem mass spectrometry.
  • Consumer behavior scores (CBS) and Tanner scale for puberty were also assessed.

Main Results:

  • Average sleep duration was 8 hours 44 minutes; 51.7% slept less than 9 hours.
  • Nonlinear associations found between hydroxy-mono-isononyl phthalate (OH-MiNP) and Mono-n-octyl phthalate (MnOP) with PSQI scores.
  • Adjusting for covariates attenuated the significance of phthalate-sleep quality associations.

Conclusions:

  • Preliminary evidence suggests potential nonlinear links between phthalate exposure and children's sleep quality.
  • Findings underscore the need for monitoring phthalate exposure in pediatric populations.
  • Further validation in larger cohorts is required to confirm these associations and implications.
Abstract

Keywords:
biomonitoringendocrine disruptorsphthalatespubertysleep quality

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