Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Flame Photometry: Overview01:02

Flame Photometry: Overview

352
Flame photometry, also known as flame emission spectrometry, is a technique used for the qualitative and quantitative analysis of elements present in a sample using a flame as the source of excitation energy. The concept of flame photometry was realized in the early 1860s by Kirchhoff and Bunsen, who discovered that specific elements emit characteristic radiation when excited in flames. The first instrument developed for this purpose was used to measure sodium (Na) in plant ash using a Bunsen...
352
Flame Photometry: Lab01:16

Flame Photometry: Lab

175
In a flame photometer, when a solution like potassium chloride is aspirated into the flame, the solvent evaporates, leaving behind dehydrated salt. This salt dissociates into free gaseous atoms in their ground state. Some of these atoms absorb energy from the flame, leading to their excitation. The excited atoms return to the ground state, emitting photons at characteristic wavelengths. Because only electronic transitions are involved, the resulting emission lines are very narrow. The intensity...
175
Types of Toxins01:36

Types of Toxins

1.3K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deciphering Pesticide Stress Responses in Rice Through Integrated Multi-Omic Assessment.

Toxics·2026
Same author

A Murine Model of Glioblastoma Initiating Cells and Human Brain Organoid Xenograft for Photodynamic Therapy Testing.

International journal of molecular sciences·2025
Same author

Coupling electrochemical and spectroscopic methods for river water dissolved organic matter characterization.

Environmental monitoring and assessment·2025
Same author

Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model.

Environmental science & technology·2023
Same author

Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy.

Cells·2023
Same author

A Multi-Level Systems Biology Analysis of Aldrin's Metabolic Effects on Prostate Cancer Cells.

Proteomes·2023

Related Experiment Video

Updated: May 10, 2025

Vegetated Treatment Systems for Removing Contaminants Associated with Surface Water Toxicity in Agriculture and Urban Runoff
08:49

Vegetated Treatment Systems for Removing Contaminants Associated with Surface Water Toxicity in Agriculture and Urban Runoff

Published on: May 15, 2017

10.5K

Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies.

Maryam Pyambri1,2, Joaquim Jaumot1, Carmen Bedia1

  • 1Environmental Chemistry Department, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.

Toxics
|April 25, 2025
PubMed
Summary

Organophosphate flame retardants (OPFRs) are replacing PBDEs but pose growing toxicity risks. New Approach Methodologies (NAMs) reveal OPFRs can harm multiple organ systems, necessitating further research for public health protection.

Keywords:
New Approach Methodologiescell culturesin vitro methodsomicsorganophosphate flame retardantstoxicity

More Related Videos

Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
08:22

Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants

Published on: December 22, 2023

451
Assessment of Chemical Toxicity in Adult Drosophila Melanogaster
07:02

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

Published on: March 24, 2023

3.1K

Related Experiment Videos

Last Updated: May 10, 2025

Vegetated Treatment Systems for Removing Contaminants Associated with Surface Water Toxicity in Agriculture and Urban Runoff
08:49

Vegetated Treatment Systems for Removing Contaminants Associated with Surface Water Toxicity in Agriculture and Urban Runoff

Published on: May 15, 2017

10.5K
Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
08:22

Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants

Published on: December 22, 2023

451
Assessment of Chemical Toxicity in Adult Drosophila Melanogaster
07:02

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

Published on: March 24, 2023

3.1K

Area of Science:

  • Environmental toxicology
  • Chemical safety
  • New Approach Methodologies (NAMs)

Background:

  • Organophosphate flame retardants (OPFRs) are increasingly used as replacements for restricted polybrominated diphenyl ethers (PBDEs).
  • Growing concerns exist regarding the toxicity and environmental persistence of OPFRs.
  • There is a need to understand the health impacts of OPFRs, especially with the shift away from animal testing.

Purpose of the Study:

  • To review current research on OPFR toxicity.
  • To highlight the application and insights gained from New Approach Methodologies (NAMs) in assessing OPFRs.
  • To inform regulatory strategies for public and environmental health protection.

Main Methods:

  • Review of existing scientific literature on OPFR toxicity.
  • Focus on studies utilizing in vitro models, omics technologies, and computational methods (NAMs).
  • Analysis of evidence regarding organ system disruption and metabolic transformation of OPFRs.

Main Results:

  • OPFRs show potential to disrupt multiple organ systems, including nervous, hepatic, pulmonary, reproductive, and endocrine systems.
  • Metabolic activation of OPFRs can lead to increased toxicity.
  • NAMs provide valuable data on cellular and molecular effects of OPFR exposure.

Conclusions:

  • OPFRs present significant toxicological concerns requiring further investigation.
  • NAMs are crucial tools for understanding OPFR toxicity and reducing animal testing.
  • Refined risk assessments and regulatory guidelines are needed to address long-term exposure risks of OPFRs.