Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and Persistence of Long-Acting Injectable Cabotegravir and Rilpivirine in Migrant Individuals Living With HIV in Spain: Substudy of the RELATIVITY Cohort.

Journal of the International AIDS Society·2026
Same author

Community-Based Screening for HIV and Viral Hepatitis Using Dried Blood Spots in a Migrant Population in Spain: The HEPINMIGRA Study.

AIDS and behavior·2026
Same author

Clinical and Epidemiological Characteristics of an Oropouche Virus Outbreak in Loreto, Peru (October 2024-March 2025).

Pathogens (Basel, Switzerland)·2026
Same author

Long-acting cabotegravir and rilpivirine in people with HIV and obesity: Real-world outcomes from the RELATIVITY cohort.

HIV medicine·2026
Same author

A prospective assessment of the efficacy and durability of long-acting cabotegravir and rilpivirine in individuals with HIV in Spain (RELATIVITY study).

The Journal of antimicrobial chemotherapy·2025
Same author

Chagas Disease in a Non-Endemic Setting: Clinical Profile, Treatment Outcomes, and Predictors of Cure in a 15-Year Cohort Study.

Tropical medicine and infectious disease·2025

Related Experiment Video

Updated: May 12, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

23.3K

Strongyloidiasis Treatment Outcomes: A Prospective Study Using Serological and Molecular Methods.

Ana Lucas Dato1,2, Philip Wikman-Jorgensen2,3,4, José María Saugar Cruz5,6

  • 1Internal Medicine/Infectious Diseases Department, Vega Baja Hospital-Orihuela, 03314 Alicante, Spain.

Tropical Medicine and Infectious Disease
|April 25, 2025
PubMed
Summary
This summary is machine-generated.

Ivermectin effectively treats chronic strongyloidiasis in over 90% of patients. This study highlights its efficacy for Strongyloides stercoralis infection, with PCR aiding in detecting persistent cases.

Keywords:
follow-upivermectinmolecular diagnosisstrongyloidiasistreatment

More Related Videos

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

15.1K
Generating Transgenics and Knockouts in Strongyloides Species by Microinjection
09:42

Generating Transgenics and Knockouts in Strongyloides Species by Microinjection

Published on: October 7, 2021

2.6K

Related Experiment Videos

Last Updated: May 12, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
10:57

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children

Published on: August 22, 2012

23.3K
Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

15.1K
Generating Transgenics and Knockouts in Strongyloides Species by Microinjection
09:42

Generating Transgenics and Knockouts in Strongyloides Species by Microinjection

Published on: October 7, 2021

2.6K

Area of Science:

  • Infectious Diseases
  • Parasitology
  • Clinical Medicine

Background:

  • Strongyloidiasis, caused by Strongyloides stercoralis, affects approximately 600 million people globally.
  • Ivermectin is the established first-line treatment for this soil-transmitted helminth infection.

Purpose of the Study:

  • To assess the long-term treatment response to ivermectin in patients with chronic strongyloidiasis.
  • To evaluate the diagnostic utility of serology and PCR in monitoring treatment efficacy.

Main Methods:

  • Prospective study involving 28 patients diagnosed with S. stercoralis infection.
  • Patients received ivermectin (200 mcg/kg for 1-2 days) and were monitored for at least 12 months.
  • Assessments included hemogram, IgE, serology, larvae culture, direct visualization, and stool PCR.

Main Results:

  • Twenty-one out of 23 patients (91.3%) who completed follow-up achieved treatment response.
  • Two patients (8.6%) showed parasitological treatment failure, confirmed by detectable S. stercoralis DNA via PCR.
  • Ivermectin demonstrated high effectiveness, with serology proving useful for monitoring.

Conclusions:

  • Ivermectin is a highly effective treatment for chronic strongyloidiasis.
  • Stool PCR offers a complementary diagnostic approach, identifying persistent infections missed by other methods.
  • Long-term follow-up is crucial for confirming sustained treatment response.