HPV Genotype Trends in Iran: Necessity for a Reevaluation of Prevention Strategies

Area of Science:

• Virology
• Oncology
• Public Health

Background:

• Human papillomavirus (HPV) genotyping is essential for managing HPV infections and related cancers.
• Understanding HPV genotype distribution and trends is vital for effective prevention strategies in Iran.

Purpose of the Study:

• To re-evaluate current HPV genotype trends in Iran.
• To forecast future HPV genotype prevalence.
• To inform targeted HPV prevention strategies and reduce cancer burden.

Main Methods:

• Cross-sectional analysis of HPV genotyping data from 2016-2022.
• Data collected from individuals tested at ACECR Khorasan Razavi molecular laboratory.
• Statistical analysis including trend analysis and linear regression, with future trend forecasting.

Main Results:

• 40.4% of 5009 female patients tested positive for HPV, with a significant upward trend in positivity over time.
• Significant increases observed in HPV genotypes 6, 11, 16, 31, 53, and 54.
• Forecasts predict increases in HPV 84 and 54, while HPV 6 is projected to decrease.

Conclusions:

• While low-risk HPV cases show a non-significant decline, high-risk HPV cases remain unchanged.
• Findings highlight the need for targeted prevention strategies in Iran, focusing on high-risk HPV genotypes.
• Further research is recommended to validate trends and refine public health interventions.