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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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Olfactory training using nasal inserts is more effective due to increased adherence.

A L Winter1, S Henecke2, E Thunell1

  • 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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|April 25, 2025
PubMed
Summary

Scented nasal inserts improve adherence to olfactory training for hyposmia (reduced sense of smell). This novel method offers comparable results to standard care with significantly lower dropout rates.

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Area of Science:

  • Otolaryngology
  • Neuroscience
  • Sensory science

Background:

  • Hyposmia, a reduced sense of smell, is typically treated with olfactory training.
  • Standard olfactory training involves smelling odors from containers twice daily for weeks.
  • Low adherence to traditional olfactory training regimens is a significant challenge.

Purpose of the Study:

  • To evaluate if scented nasal inserts can enhance adherence to olfactory training for hyposmia.
  • To compare the effectiveness of nasal inserts versus standard care in improving olfactory ability.
  • To assess the impact of nasal inserts on patient mobility and perceived intrusion during training.

Main Methods:

  • A randomized controlled trial with 116 participants with hyposmia.
  • Olfactory training was conducted for 8 weeks.
  • One group used scented nasal inserts; the control group received standard care.

Main Results:

  • Both groups showed significant improvements in objective and subjective olfactory abilities.
  • Nasal inserts resulted in similar overall treatment outcomes compared to standard care.
  • The nasal insert group demonstrated significantly higher adherence and a lower dropout rate (6.7% vs. 23.2%).

Conclusions:

  • Olfactory training with nasal inserts represents a more effective treatment for hyposmia.
  • Improved adherence and completion rates contribute to the efficacy of nasal inserts.
  • Nasal inserts offer a promising, less intrusive alternative for olfactory training.