Related Experiment Video
Updated: Jul 14, 2026
Detecting Behavioral Deficits in Rats After Traumatic Brain Injury
Published on: January 30, 2018
Results of therapy in children diagnosed with severe traumatic brain injury
Tatyana Sakharova1, Dimitar Monov2, Nikolay Lilyanov3
1Department of Biology and General Genetic, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Insights
Optimizing infusion therapy and monitoring hydrobalance in pediatric severe craniocerebral trauma (SCCT) improves patient outcomes. Positive hydrobalance and adequate rehydration are crucial for better prognosis in children with SCCT.
Area of Science:
- Pediatric critical care medicine
- Neurotraumatology
- Pediatric intensive care
Background:
- Severe craniocerebral trauma (SCCT) in children presents significant challenges in therapeutic management.
- Understanding contributing factors to cerebral injury is vital for improving outcomes in pediatric SCCT patients.
Purpose of the Study:
- To evaluate the impact of infusion therapy on pediatric patients with SCCT, focusing on hydrobalance indicators.
- To assess adaptive changes in humoral stress response, including hormone concentrations (TSH, cortisol, prolactin), plasma protein, and glucose levels in SCCT.
- To identify prognostic indicators for SCCT in children.
Main Methods:
- A study involving 804 children with isolated severe craniocerebral trauma (SCCT), divided into retrospective and prospective cohorts.
- Analysis of hydrobalance indicators, hormone concentrations (TSH, cortisol, prolactin), plasma protein, and glucose levels.
- Comparison of outcomes based on hydrobalance status (positive vs. negative) and correlation of biochemical markers with prognosis.
Main Results:
- Children with negative hydrobalance had a significantly higher mortality rate (24%) compared to those with positive hydrobalance (10%).
- Positive hydrobalance, coupled with appropriate infusion therapy and rehydration, positively influenced SCCT prognosis.
- Higher total protein levels were observed in conscious children post-trauma compared to deceased individuals. Stress-induced hyperglycemia correlated with SCCT severity.
Conclusions:
- Infusion therapy is critical for managing pediatric SCCT, with positive hydrobalance being a key factor for improved prognosis.
- Indicators such as total protein, glucose, and prolactin concentrations are valuable for assessing SCCT severity and predicting outcomes.
- Clinical application of these findings can optimize treatment strategies and enhance recovery for children with SCCT.
Abstract:
The aim of this research is to enhance therapeutic outcomes in children diagnosed with severe craniocerebral trauma by evaluating the contributing factors involved in cerebral injury. The investigation focused on evaluating the impact of infusion therapy on the improvement of pediatric patients' conditions with SCCT, particularly by assessing hydrobalance indicators. Adaptive changes associated with the humoral stress response were evaluated through alterations in hormone concentrations (thyrotropin (TSH), cortisol (C), prolactin (P)). Concentrations of plasma protein and glucose were analyzed. A total of 804 children with isolated severe craniocerebral trauma (SCCT) were enrolled and stratified into retrospective (n = 474) and prospective (n = 100) cohorts. Children with negative hydrobalance exhibited a higher mortality rate compared to those with positive hydrobalance (24% vs. 10%, p ≤ 0.05). Positive hydrobalance, in conjunction with appropriate infusion therapy and rehydration, positively influenced the prognosis of severe cranio-cerebral trauma (SCCT). These findings can be applied in clinical practice to optimize the treatment of children with SCCT and improve their prognosis. The level of total protein was higher in conscious children after 48 h (59.9 ± 1.5 g/L, p ≤ 0.05) in comparison to deceased individuals (54.9 ± 1.6 g/L, p ≤ 0.05). Stress-induced hyperglycemia was associated with the severity of severe cranio-cerebral trauma. The study corroborated the significance of infusion therapy in the treatment of children with SCCT. Indicators of total protein, glucose, and P concentrations can serve as valuable tools for assessing the severity and prognostication of SCCT.
