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The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
Chondrosarcoma in the Posterior Maxilla Region
Jonathan França da Silva Cavalcanti1,2,3, Márcia Maria da Fonseca Silveira4, Weslay Rodrigues da Silva4,5
1Department of Oral and Maxillofacial Pathology, School of Dentistry, Postgraduate Program in Dentistry, Universidade de Pernambuco (UPE), Recife, Pernambuco, Brazil. jonathan.francasc@upe.br.
Background:
Chondrosarcoma is a malignant neoplasm characterized by the production of a cartilaginous matrix.
Case Report:
We present the case of a 58-year-old male patient referred to the maxillofacial surgery and traumatology service due to swelling in the posterior region of the right maxilla, with a duration of 8 months, and a previous history of a fibro-osseous lesion in the region. Intraoral examination revealed a rounded lesion with ulceration, firm upon palpation, in the area of teeth 17 and 18. The panoramic radiograph revealed a radiopaque lesion with a flocculated pattern in the right maxilla, and computed tomography showed a hyperdense lesion containing hypodense areas. Histopathological analysis revealed the presence of immature cartilage, with rounded neoplastic cells, nuclei of varied sizes, and intense pleomorphism, leading to a diagnosis of chondrosarcoma. The patient underwent surgical resection followed by radiotherapy and, after one year of follow-up, has shown no signs of recurrence.
Conclusions:
Although rare in gnathic bones, chondrosarcoma should be considered in the differential diagnosis of osseous enlargement in this region.
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