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Updated: May 10, 2025

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Peptide bonds strike back
1Research Group for Structural Biochemistry and Mechanisms, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, D-37077 Göttingen, Germany.
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Recent advances in protein design and protein structure prediction have questioned whether experimental structural biology still has a role to play in research today. The article by Panjikar and Weiss [(2025). IUCrJ, 12, 307-321] partially answers this question and alludes to a role still to be played by structural biology. Several properties of peptide bonds, likely important for function, are described that are absent in protein design and predicted protein structures, and that have largely been overlooked by the structural biology community.
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