Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes
Ming-Yi Zhang1, Yu-Chang Liu1, Xing-Yu Liu1
1Department of Basic Medicine, College of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Abstract:
Psoriasis is a chronic disease with elusive pathogenesis linked to genetic, and immune factors. Studies have shown most patients have experienced high levels of oxidative stress, which can lead to inflammation or damage. Withaferin A is a natural product with multiple pharmacological activities, including anti-tumor and anti-inflammatory effects. We investigated the effects of WA in treating Imiquimod (IMQ)-induced psoriasis mice. The epidermal pathology of mice was significantly improved after treatment. WA inhibited inflammation by decreasing the production of IL-1β, IL-6, and IFN-γ, which were induced by epidermal oxidative stress. Additionally, WA can shift the macrophage status from pro-inflammatory to anti-inflammatory.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Clinical Applications of Epidermal Stem Cells
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Renewal of Skin Epidermal Stem Cells


