JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

[Elevated neutrophil-lymphocyte ratio and delayed graft function]

  • 0Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Especialidades No.1, Servicio de Nefrología. León, Guanajuato, México.
Revista Médica Del Instituto Mexicano Del Seguro Social +

|

April 25, 2025

|

April 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The neutrophil-to-lymphocyte ratio (NLR) does not predict delayed graft function in kidney transplants. Donor acute kidney injury is a significant risk factor for DGF post-transplantation.

Area Of Science

  • Nephrology
  • Transplantation immunology
  • Inflammatory markers

Context

  • Delayed graft function (DGF) is a critical complication impacting kidney transplant outcomes.
  • Predictive tools for DGF are essential for improving graft and recipient survival.
  • Elevated neutrophil-to-lymphocyte ratio (NLR) has been investigated as a potential inflammation-based predictor of DGF.

Purpose

  • To investigate the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and the incidence of delayed graft function (DGF) in kidney transplant recipients.

Summary

  • A prospective study analyzed kidney transplant recipients, assessing preoperative NLR levels.
  • Results indicated that an NLR > 3.5 showed 80% specificity and 28% sensitivity for DGF.
  • No significant association was found between elevated preoperative NLR and DGF.

Impact

  • The study suggests that preoperative NLR is not a reliable predictor of DGF.
  • Donor acute kidney injury emerged as a strong independent risk factor, increasing DGF likelihood by nearly 200%.
  • Findings highlight the need to focus on donor-related factors for DGF risk assessment.

Keywords: