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Updated: May 13, 2025
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Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
Published on: June 7, 2017
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[Elevated neutrophil-lymphocyte ratio and delayed graft function].
Itzy Maely Gaytán-Campos1, Aurelio Chávez-Meza1, José Oscar Juaréz-Sánchez1
1Instituto Mexicano del Seguro Social, Centro Médico Nacional del Bajío, Hospital de Especialidades No.1, Servicio de Nefrología. León, Guanajuato, México.
Revista Medica Del Instituto Mexicano Del Seguro Social
|April 25, 2025
Summary
The neutrophil-to-lymphocyte ratio (NLR) does not predict delayed graft function in kidney transplants. Donor acute kidney injury is a significant risk factor for DGF post-transplantation.
Area of Science:
- Nephrology
- Transplantation immunology
- Inflammatory markers
Context:
- Delayed graft function (DGF) is a critical complication impacting kidney transplant outcomes.
- Predictive tools for DGF are essential for improving graft and recipient survival.
- Elevated neutrophil-to-lymphocyte ratio (NLR) has been investigated as a potential inflammation-based predictor of DGF.
Purpose:
- To investigate the association between preoperative neutrophil-to-lymphocyte ratio (NLR) and the incidence of delayed graft function (DGF) in kidney transplant recipients.
Summary:
- A prospective study analyzed kidney transplant recipients, assessing preoperative NLR levels.
- Results indicated that an NLR > 3.5 showed 80% specificity and 28% sensitivity for DGF.
- No significant association was found between elevated preoperative NLR and DGF.
Impact:
- The study suggests that preoperative NLR is not a reliable predictor of DGF.
- Donor acute kidney injury emerged as a strong independent risk factor, increasing DGF likelihood by nearly 200%.
- Findings highlight the need to focus on donor-related factors for DGF risk assessment.
