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BBr3-Mediated ortho C-H Borylation of Benzamides
Yixuan Liang1, Chengyu Du1, Chengwen Dong1
1Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education and Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan 430074, P. R. China.
Abstract:
We have developed a BBr3-mediated, metal-free ortho C-H borylation of benzamides, enabling the synthesis of a wide range of ortho-borylated benzamides in moderate to good yields. This transformation offers a convenient strategy for accessing functionalized benzamides, which are valuable intermediates in pharmaceuticals, agrochemicals, and fine chemical synthesis.
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