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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Results from a multiple sclerosis relapse clinic.

Ger Mullan1, Rachael Kee1, Fiona Kennedy2

  • 1Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, United Kingdom; Department of Neurology, Belfast Health and Social Care Trust, United Kingdom.

Multiple Sclerosis and Related Disorders
|April 25, 2025
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Summary
This summary is machine-generated.

Multiple sclerosis (MS) relapse clinics rarely diagnose actual relapses; pseudorelapses are more common. This highlights the need for careful clinical evaluation before prescribing treatments like corticosteroids for MS symptoms.

Keywords:
MSMultiple sclerosisPseudorelapseRelapseRelapse clinic

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Area of Science:

  • Neurology
  • Clinical Medicine
  • Healthcare Management

Background:

  • Multiple sclerosis (MS) relapse clinics aim for early diagnosis and management of MS relapses.
  • Published outcome data from MS relapse clinics are limited, hindering understanding of their real-world utility.

Purpose of the Study:

  • To analyze the outcomes of a specific MS relapse clinic over a 12-month period.
  • To determine the frequency of confirmed MS relapses versus other presentations at the clinic.
  • To assess the utilization of corticosteroid therapy in the context of clinic attendances.

Main Methods:

  • Retrospective analysis of patient data from the Belfast Health and Social Care Trust (BHSCT) relapse clinic.
  • Inclusion of all attendances over a defined 12-month period.
  • Review of diagnostic criteria, including new neurological symptoms and radiological evidence of disease activity.

Main Results:

  • Only 16% of attendees were diagnosed with a confirmed MS relapse.
  • Pseudorelapse was identified as a more frequent reason for presentation (19%) than actual relapse.
  • Corticosteroid therapy was administered in a low percentage (3%) of all attendances.

Conclusions:

  • The low rate of confirmed relapses underscores the importance of thorough clinical evaluation for new neurological symptoms.
  • Findings suggest a need for caution in prescribing corticosteroids for suspected MS relapses.
  • The results may indicate the impact of highly effective disease-modifying therapies on relapse rates.
  • Encourages publication of relapse clinic data to better characterize relapse frequency and service utility.