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Striato-cortical connectivity patterns predict clinical profiles in Huntington's disease

Audrey E De Paepe1, Vasiliki Bikou2, Eylül Turan3

  • 1Cognition and Brain Plasticity Unit [Bellvitge Biomedical Research Institute - IDIBELL], 08097 L'Hospitalet de Llobregat, Barcelona, Spain; Department of Cognition, Development and Education Psychology, Universitat de Barcelona, Barcelona, Spain.

Neuroimage. Clinical
|April 25, 2025
PubMed
Summary

Distinct clinical profiles in Huntington's disease, motor-cognitive and behavioral, are linked to unique brain connectivity patterns. This research reveals how striato-cortical circuits change in Huntington's disease.

Keywords:
Clinical profilesHuntington’s diseaseIndividual differencesPrincipal component analysisrs-fMRI

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