Related Experiment Video
Updated: May 22, 2025

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Muscle Damage and the Repeated-bout Effect After a Typical Nordic Hamstring Exercise Session
Giuseppe Coratella1, Emiliano Cè1, Antonio D'Orlando1
1Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milano, Italy.
Abstract:
The present study investigated muscle damage and the repeated-bout effect after a typical Nordic hamstring exercise session. Thirteen trained male adults were recruited. Muscle damage was monitored through eccentric strength, passive range of motion, muscle soreness, and muscle swelling. Assessments were performed at baseline and 1 (day 1), 2 (day 2), 3 (day 3), and 4 (day 4) days after 24 Nordic hamstring exercise repetitions. The procedures were replicated after 4 weeks to examine the repeated-bout effect. After the first bout, the hamstring eccentric strength decreased up to day 3 (effect size range:-2.28/-1.95). The passive range of motion decreased up to day 4 (effect size range:-1.62/-0.64), while the muscle soreness increased on day 2 (effect size=1.63) and day 3 (effect size=1.53). No change in muscle swelling was observed. After the second bout, the hamstring eccentric strength (effect size=- 1.20) decreased only on day 1. The passive range of motion decreased up to day 3 (effect size=- 0.85/-0.34). These changes were by a smaller magnitude compared to the first bout. The first Nordic hamstring exercise bout impaired hamstring strength and passive range of motion, with muscle soreness also perceived, while the second bout reduced muscle damage symptoms and shortened the time to recovery. While recovery is needed when a Nordic hamstring exercise session is performed for the first time, following Nordic hamstring exercise sessions may scarcely interfere with the training routine.
More Related Videos
Related Concept Videos
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Muscle Recovery and Fatigue
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

