Biocompatible narrow size nanohydrogels for drug delivery

Biodegradable polymers have gained attention for controlled drug delivery due to their potential for sustained release. Herein, a novel series of cross-linked, narrow size nanohydrogels (NHGs) with tunable sizes (20-500 nm), devoid of toxicity, and suitable for diverse biological applications were developed. These NHGs are synthesized via a thermo-responsive self-assembly process followed by confined polymerization. Ester cross-linkers were introduced into the polymeric backbone to enhance biodegradability. The NHGs comprise ideal candidates for drug delivery due to their long circulation in blood after iv administration. The anti-oxidant curcumin and the antifungal drug amphotericin B (AmB) as hydrophobic drug models were successfully loaded. The AmB-loaded NHGs showed improved antifungal activity against clinical isolates of molds and yeasts and markedly reduced morbidity in murine models inoculated with lethal doses of the pathogenic mold Candida albicans as compared to the commercial AmB formulation Fungizone. The NHGs thereby offer a versatile platform for controlled drug release.