Liver DNA synthesis after phenytoin injection in adult NMRI mice

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Cell and Tissue Kinetics

|September 1, 1985

Abstract:

Stimulation of hepatocyte DNA synthesis was observed in adult mice, as measured by the number of parenchymal cells in S phase, at two different times after a single i.p. injection of diphenylhydantoin (DPH): 18 and 25 hr. No such stimulation was obtained for Kupffer or endothelial cells.

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