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Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
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Cancer risk according to lifestyle risk score trajectories: a population-based cohort study
Thi Minh Thu Khong1, Thi Tra Bui1, Hee-Yeon Kang1
1National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.
BJC Reports
|April 25, 2025
Summary
Tracking unhealthy lifestyle score trajectories is crucial for cancer prevention. High-risk trajectories significantly increase the risk of developing various cancers, highlighting the importance of healthy habits.
Area of Science:
- Epidemiology
- Public Health
- Oncology
Background:
- Individual lifestyle behaviors are linked to cancer risk, but their combined impact is not well understood.
- This study investigates the influence of combined lifestyle risk factors on cancer incidence in Korea.
Purpose of the Study:
- To analyze the association between lifestyle risk score trajectories and cancer risk.
- To identify patterns of unhealthy behaviors and their impact on cancer development.
Main Methods:
- Utilized a large cohort of 3,451,189 Korean adults from health examination data (2002-2003).
- Group-based trajectory modeling assessed lifestyle risk scores (smoking, alcohol, weight, inactivity) from 2002-2007.
- Cox proportional hazards models examined cancer incidence from 2008-2019.
Main Results:
- Identified seven trajectories in men and four in women based on lifestyle risk scores.
- High-risk lifestyle trajectories correlated with increased risk for most cancers, including lung, liver, and colorectal cancer.
- An inverse association was noted for prostate cancer risk in men with high-risk trajectories.
Conclusions:
- Adopting and maintaining healthy lifestyle behaviors is vital for effective cancer prevention.
- Reducing combined unhealthy behaviors can mitigate cancer risk across diverse populations.
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