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Significance of preoperative mean corpuscular volume in patients with stage II/III colorectal cancer and anemia

  • 0Department of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
International Journal of Clinical Oncology +

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April 25, 2025

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April 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Mean corpuscular volume (MCV) levels can predict colorectal cancer (CRC) recurrence. Low MCV (<80 fL) indicates favorable recurrence-free survival (RFS), while high MCV (≥100 fL) suggests worse RFS, especially in patients with anemia.

Area Of Science

  • Oncology
  • Hematology

Background

  • Inconsistent findings exist regarding mean corpuscular volume (MCV) and colorectal cancer (CRC) prognosis.
  • Preoperative MCV's association with recurrence-free survival (RFS) in CRC requires further investigation.

Purpose Of The Study

  • To investigate the association between preoperative mean corpuscular volume (MCV) and recurrence-free survival (RFS) in patients with colorectal cancer (CRC).

Main Methods

  • Analysis of 1876 patients with stage II/III CRC who underwent R0 resection.
  • Univariate and multivariate analyses to determine relationships between clinicopathological factors and RFS.
  • Examination of MCV's prognostic significance in various clinicopathological contexts, defining anemia as Hb <13 g/dL (men) or <12 g/dL (women).

Main Results

  • Multivariate analysis identified MCV as a significant independent risk factor for RFS in CRC patients.
  • MCV <80 fL was associated with a 0.60 hazard ratio for recurrence, while MCV ≥100 fL had a 1.76 hazard ratio (p<0.033) compared to MCV 80-100 fL.
  • The prognostic impact of MCV was more pronounced in patients with anemia, with 5-year RFS rates of 83.4% for MCV <80 fL and 58.9% for MCV ≥100 fL.

Conclusions

  • Preoperative MCV levels <80 fL and ≥100 fL can indicate favorable and worse RFS, respectively.
  • These findings are particularly relevant for patients with stage II/III CRC and anemia.
  • MCV serves as a valuable prognostic indicator in specific CRC patient subgroups.

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