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Related Experiment Video

Updated: May 10, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Maternal IgE Influence on Fetal and Infant Health.

Jozef Balla¹, Abhay P S Rathore^1,2, Ashley L St John^1,2,3,4

¹Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.

Immunological Reviews

|April 25, 2025

Summary

Maternal immunoglobulin E (IgE) transfers to infants, influencing early immune development and allergy risk. Understanding this transfer is key to preventing childhood allergies.

Keywords:

FcRn receptor Th2 immune response allergic disease development antibody glycosylation anti‐IgE IgG immune complex breast milk mast cells placental transfer

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

Area of Science:

Immunology
Allergy Research
Maternal-Fetal Medicine

Background:

Immunoglobulin E (IgE) is crucial for immune responses against parasites but can cause allergies.
Allergic diseases often originate early in life, with maternal factors playing a significant role.
The source of fetal IgE and its early developmental impact remain areas of active investigation.

Purpose of the Study:

To review mechanisms of maternal IgE transfer to offspring.
To examine IgE interactions with fetal immune cells and their consequences.
To explore how maternal IgE influences the development of allergic inflammation and sensitization.

Main Methods:

Literature review of existing research on IgE, mast cells, and maternal-fetal immune interactions.
Analysis of studies investigating IgE transfer across the placenta or via other routes.
Synthesis of data on the functional impact of maternal IgE on offspring immunity.

Main Results:

Maternal IgE can be transferred to the fetus, potentially influencing immune system development.
Pre-existing maternal antibodies (IgG, IgE) and their glycosylation affect IgE transfer and function.
Maternal IgE interacts with offspring mast cells and antigen-presenting cells, impacting allergic responses.

Conclusions:

Maternal IgE transfer is a significant factor in early life allergy development.
Understanding these mechanisms can inform therapeutic strategies for preventing and treating childhood allergies.
Targeting maternal IgE pathways may offer new avenues for allergy prevention.