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Exploring the Cardiovascular Potential of Artichoke-A Comprehensive Review
Henrique Silva1,2,3, Avina Mahendra Daia2
1Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal.
Biology
|April 26, 2025
Summary
Artichoke (Cynara cardunculus) may support cardiovascular health by improving blood vessel function and aiding blood pressure regulation. However, its role as an adjunct therapy requires further research with standardized formulations.
Area of Science:
- Cardiovascular Pharmacology
- Nutraceutical Research
- Herbal Medicine
Background:
- Cardiovascular disease is a major global health concern, necessitating diverse preventive strategies.
- Artichoke (Cynara cardunculus) exhibits potential health benefits, including lipid-lowering and choleretic effects.
- The cardiovascular impact of artichoke requires further investigation.
Purpose of the Study:
- To critically review the existing literature on the cardiovascular effects of artichoke.
- To explore the mechanisms of action and clinical efficacy of artichoke for cardiovascular health.
- To assess artichoke's potential role in managing hypertension and improving endothelial function.
Main Methods:
- Review of experimental studies on endothelial function, vascular smooth muscle relaxation, and the renin-angiotensin-aldosterone axis.
- Analysis of clinical studies, systematic reviews, and meta-analyses on artichoke's antihypertensive effects.
- Assessment of bioactive components like flavonoids and caffeoylquinic acids.
Main Results:
- Artichoke components promote vasorelaxation and inhibit angiotensin-converting enzyme.
- Clinical studies show improvements in flow-mediated dilation.
- Modest blood pressure reduction observed, with significant variability in study designs and outcomes.
Conclusions:
- Artichoke supplementation may benefit blood pressure regulation and endothelial health.
- Current evidence supports artichoke as an adjunct to conventional antihypertensive treatments.
- Further research with standardized artichoke formulations is needed to define its therapeutic role.
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