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Updated: May 10, 2025

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
Role of Neutrophils in Anti-Tumor Activity: Characteristics and Mechanisms of Action
Xin Chen1, Bingdi Chen2, Huadong Zhao1
1Department of General Surgery, Tangdu Hospital, Air Force Medical University, Xi'an 710032, China.
Abstract:
As one of the leading components in the immune system, neutrophils in the tumor microenvironment (TME) have received considerable attention in recent years. The tumor-killing effects of neutrophils in a variety of tumors have been reported. However, the functions of neutrophils in tumors remain to be completely elucidated, and both anti-tumor and tumor-promotion activities have been reported. This review focuses on the characteristics of neutrophils and their mechanisms of action in the TME, with an emphasis on their anti-tumor activity, including reactive oxygen species (ROS)-induced tumor killing, cytotoxic T lymphocytes (CTLs)-induced tumor killing, trogocytosis, cytotoxic enzymes, and trained immunity. Furthermore, the possible targets and methods of tumor treatment regimens for neutrophils are explored, with the aim of exploring the use of neutrophils in the future as a potential anti-tumor treatment strategy.
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