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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Related Experiment Video

Updated: Jun 11, 2026

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
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The Impact of Aortic Calcification on Surgical Outcomes in Colorectal Cancer Patients: A Retrospective Analysis

Veysel Barış Turhan1, Onur Karacif2, Mehmet Berksun Tutan3

  • 1Department of General Surgery, Faculty of Medicine, Hitit University, 19030 Çorum, Turkey.

Medicina (Kaunas, Lithuania)
|April 26, 2025
PubMed
Summary

Severe aortic calcification (AC) significantly increases the risk of anastomotic leakage (AL) after colorectal surgery (CRS). This finding highlights the importance of assessing AC in patients undergoing CRS to improve outcomes.

Keywords:
anastomotic leakaortic calcificationcolorectal surgeryvascular health

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Area of Science:

  • Vascular Surgery
  • Gastrointestinal Oncology
  • Radiology

Background:

  • Anastomotic leakage (AL) is a critical complication following colorectal surgery (CRS), leading to increased morbidity, mortality, and healthcare costs.
  • Existing research has identified several risk factors for AL, but the specific role of aortic calcification (AC), a marker of systemic atherosclerosis, remains underexplored.
  • AC may negatively impact tissue perfusion and wound healing, potentially increasing AL risk in CRS patients.

Purpose of the Study:

  • To investigate the association between preoperative aortic calcification (AC) and the incidence of anastomotic leakage (AL) in patients undergoing colorectal surgery (CRS).
  • To evaluate AC as an independent predictor of AL while accounting for other known risk factors, including tumor characteristics and patient comorbidities.

Main Methods:

  • A retrospective cohort study involving 151 patients who underwent CRS between January 2020 and October 2023.
  • Preoperative CT scans were used to classify the severity of aortic calcification (AC) into three stages based on the percentage of the aortic circumference affected.
  • Data on patient demographics, tumor details, neoadjuvant therapy, and comorbidities were collected and analyzed using univariate and multivariate logistic regression.

Main Results:

  • The overall incidence of anastomotic leakage (AL) was 5.96%.
  • Patients with severe AC (>50% of aortic circumference) exhibited a significantly higher incidence of AL (44.47%) compared to those with no or mild AC (11.27%, p=0.012).
  • Multivariate analysis identified severe AC as an independent predictor of AL (OR=10.38, p=0.032), alongside rectal tumor localization, hypertension, cardiovascular disease, and neoadjuvant therapy.

Conclusions:

  • Severe aortic calcification (AC) is a significant and independent predictor of anastomotic leakage (AL) in patients undergoing colorectal surgery (CRS).
  • Factors such as rectal tumor location, hypertension, cardiovascular disease, and neoadjuvant therapy also contribute to the risk of AL.
  • Implementing preoperative vascular assessments and comprehensive risk stratification models is crucial for identifying high-risk patients and optimizing perioperative management to reduce AL incidence.