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Role of Progesterone Receptor Level in Predicting Axillary Lymph Node Metastasis in Clinical T1-T2N0 Luminal Type Breast Cancer

  • 0Department of Radiation Oncology, University of Health Sciences Izmir College of Medicine and Izmir City Hospital, 35540 Izmir, Turkey.
Medicina +

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April 26, 2025

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April 26, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Lower progesterone receptor (PR) expression below 80% is linked to a higher risk of axillary lymph node metastasis in early-stage breast cancer. This finding aids in predicting metastasis risk for better patient outcomes.

Area Of Science

  • Oncology
  • Breast Cancer Research
  • Cancer Biomarkers

Background

  • Axillary lymph node metastasis is a critical prognostic factor in breast cancer, impacting overall survival.
  • Predicting lymph node involvement in early-stage breast cancer is crucial for treatment planning.
  • Progesterone receptor (PR) expression is associated with prognosis, particularly in luminal A breast cancer.

Purpose Of The Study

  • To investigate the relationship between the percentage of progesterone receptor (PR) expression and the likelihood of axillary lymph node metastasis.
  • To evaluate this association in Her-2-negative, clinical T1-T2N0 luminal type breast cancer patients.

Main Methods

  • Retrospective analysis of 199 breast cancer cases with specific clinical and pathological characteristics.
  • Inclusion criteria: luminal type, Her-2-negative, clinically and radiologically axilla-negative T1-T2 breast cancer treated with radiotherapy.
  • Pathological specimens were reviewed by an experienced pathologist to assess PR expression levels.

Main Results

  • Tumor diameter greater than 2 cm was a significant predictor of lymph node positivity (p = 0.003).
  • Lymphovascular invasion was strongly associated with lymph node metastasis (p = 0.001).
  • Progesterone receptor (PR) expression level below 80% emerged as a significant predictor of lymph node positivity (p = 0.037).

Conclusions

  • The percentage of progesterone receptor (PR) expression is a valuable predictor of axillary metastasis risk.
  • Integrating PR expression with other clinicopathological parameters and molecular markers improves the prediction of lymph node involvement.
  • This comprehensive evaluation is essential for risk stratification before surgical intervention in breast cancer patients.

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