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Asprosin and Neuregulin 4 in Obesity in Children

Ramazan Dulkadir1, Gamze Turna Saltoglu2, Ali Gunes1

  • 1Department of Pediatrics, Faculty of Medicine, Kirsehir Ahi Evran University, Kirsehir 40100, Turkey.

Medicina (Kaunas, Lithuania)
|April 26, 2025
PubMed

Insights

Pediatric obesity research found neuregulin 4 levels higher in normal-weight children, while asprosin levels were similar. Further studies are needed to understand these adipokines

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Obesity Research

Background:

  • Childhood obesity is a significant global nutritional challenge.
  • Adipokines like asprosin and neuregulin 4 are emerging factors in metabolic health.
  • Understanding novel adipokine roles in pediatric obesity is crucial.

Purpose of the Study:

  • To investigate serum concentrations of asprosin and neuregulin 4 in pediatric obesity.
  • To correlate these adipokines with obesity-related anthropometric and biochemical markers.
  • To compare adipokine levels between obese children and normal-weight controls.

Main Methods:

  • Cross-sectional study comparing 40 obese children with 40 normal-weight children.
  • Serum levels of asprosin and neuregulin 4 were measured.
  • Anthropometric, biochemical (including HOMA-IR), and hormonal parameters were assessed.

Main Results:

  • Asprosin serum levels did not differ significantly between obese and normal-weight children.
  • Neuregulin 4 and HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) were significantly elevated in the obese group (p < 0.05).
  • Neuregulin 4 levels were found to be higher in normal-weight children compared to obese children.

Conclusions:

  • Neuregulin 4 may play a complex role in pediatric obesity, with lower levels observed in obese children.
  • Asprosin does not appear to be a differentiating factor in pediatric obesity in this cohort.
  • Further research is essential to elucidate the precise roles of asprosin and neuregulin 4 in childhood obesity.

Keywords:
asprosinchildneuregulin 4obesity

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