Related Experiment Video
Updated: May 10, 2025
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
2.7K
Type 1 Diabetes/Hidradenitis Suppurativa Comorbidity-A Population-Based Study
Shany Sherman1,2, Ron Slama2, Danielle Bar2
1Division of Dermatology, Rabin Medical Center, Beilinson Hospital, Petach Tikva 4941492, Israel.
Journal of Clinical Medicine
|April 26, 2025
Summary
Type 1 diabetes (T1D) is linked to a higher risk of developing hidradenitis suppurativa (HS). This association highlights the need for awareness of this comorbidity due to increased metabolic and autoimmune issues.
Area of Science:
- Endocrinology
- Dermatology
- Epidemiology
Background:
- Type 1 diabetes (T1D) and hidradenitis suppurativa (HS) share inflammatory and metabolic dysfunctions.
- Previous research suggested a link but lacked validated T1D diagnoses or showed only indirect associations.
Purpose of the Study:
- To determine the odds of HS development in patients with a validated T1D diagnosis.
- To characterize clinical features of HS/T1D comorbidity.
Main Methods:
- Population-based nested case-control study.
- Included 10,919 HS patients and 53,314 controls, matched 5:1.
- Validated T1D diagnosis using a specialized algorithm and expert review.
Main Results:
- T1D history was associated with significantly higher odds of new-onset HS (OR 1.80, aOR > 1.7).
- HS/T1D patients had more autoimmune conditions and higher comorbidity burden (Charlson Index 3.5) than HS or T1D alone.
- Adjusted analyses confirmed the association after controlling for confounders.
Conclusions:
- Type 1 diabetes is associated with increased odds of subsequent hidradenitis suppurativa.
- Awareness of HS/T1D comorbidity is recommended due to the elevated burden of metabolic and autoimmune conditions.
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
475
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
475
01:20Pathophysiology of Diabetes
807
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
807
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
01:19Psychoneuroimmunology: Diabetes and Cancer
19
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
19