Related Experiment Video

Updated: May 12, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.0K

Intraventricular Thrombosis After Myocardial Infarction: Prognostic Evaluation in Relation to Microvascular

Antonella Cecchetto1,2, Francesco Zupa2, Manuel De Lazzari1,2

  • 1Cardiology Unit, University of Padua-Azienda Ospedaliera, 35128 Padua, Italy.

Journal of Clinical Medicine
|April 26, 2025
PubMed

Insights

Patients with left ventricular thrombosis after myocardial infarction treated with anticoagulation have a worse prognosis. Microvascular obstruction extent did not worsen outcomes in these patients.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Interventional Cardiology

Background:

  • Limited data exists on anticoagulation therapy for left ventricular thrombosis (LV thrombosis) post-ST-segment elevation myocardial infarction (STEMI).
  • Assessing the impact of microvascular obstruction (MVO) on prognosis in STEMI patients with LV thrombosis is crucial.

Purpose of the Study:

  • To evaluate the prognostic impact of MVO extent on cardiac magnetic resonance (CMR) in STEMI patients with LV thrombosis receiving anticoagulation.
  • To determine if MVO exacerbates the adverse outcomes associated with LV thrombosis.

Main Methods:

  • Retrospective analysis of 80 STEMI patients undergoing CMR after reperfusion therapy.
  • Patients categorized into four groups based on MVO and LV thrombosis presence.
  • Major adverse cardiac events (MACE) tracked during an 11-month follow-up period.

Main Results:

  • LV thrombosis, treated with anticoagulation, independently predicted MACE (HR 2.828, p=0.017).
  • Patients with LV thrombosis showed a significantly worse prognosis (p=0.012) compared to those without.
  • The extent of MVO did not significantly influence prognosis in patients with LV thrombosis (p=0.852).

Conclusions:

  • Anticoagulation therapy for LV thrombosis post-STEMI is associated with a poorer prognosis.
  • MVO extent does not appear to be an additional risk factor for adverse outcomes in this patient cohort.

Keywords:
anticoagulationintraventricular thrombosisleft ventricular remodelingmicrovascular obstruction

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.4K
Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.2K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...