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Rapid-Acting Treatments for Perinatal Depression: Clinical Landscapes and Future Horizons

Emily M Beydler1,2, Amanda Koire3,4,5, Elizabeth Steuber5,6

  • 1Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.

International Journal of Environmental Research and Public Health
|April 26, 2025
PubMed

Perinatal depression affects approximately 1 in 5 women and is the leading cause of maternal mortality in the United States. In addition to evidence-based treatment with antidepressant medications, there has been a push to identify rapid-acting options for pregnant and postpartum individuals. This paper reviews the evidence behind new pharmacological agents (neurosteroids and ketamine) and non-pharmacological approaches (transcranial magnetic stimulation). The paper also highlights the risks and benefits of electroconvulsive therapy and selective serotonin reuptake inhibitors. Based on recent studies and research, the paper provides considerations when prescribing these modalities including: timing of symptom onset, severity of presentation, breastfeeding priorities, prior treatment response and treatment availability and cost.

Keywords:
antidepressantsneurosteroidsperinatal depressiontranscranial magnetic stimulation

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